Mounjaro vs Zepbound
Quick Facts
- Type: GLP-1/GIP
- FDA Approval: Mounjaro (2022), Zepbound (2023)
- Frequency: Once weekly
Weight Loss Data
- Mounjaro: 15-20% in 72 weeks
- Zepbound: 15-20% in 72 weeks
Primary Uses
- •Type 2 Diabetes
- •Weight Management
- •Blood Sugar Control
- •Obesity Treatment
Medication Overview
Mounjaro
GLP-1/GIPBasic Information
- Generic Name: tirzepatide
- Manufacturer: Eli Lilly
- FDA Approval: 2022
Key Benefits
- ✓Superior A1C reduction compared to other GLP-1s
- ✓Significant weight loss potential
- ✓Dual-action mechanism
- ✓Once-weekly dosing
Zepbound
GLP-1/GIPBasic Information
- Generic Name: tirzepatide
- Manufacturer: Eli Lilly
- FDA Approval: 2023
Key Benefits
- ✓Significant weight loss potential
- ✓Dual-action mechanism
- ✓Once-weekly dosing
- ✓Improved metabolic health
Dosing Information
| Dosing Details | Mounjaro | Zepbound |
|---|---|---|
| Starting Dose | 2.5mg | 2.5mg |
| Maintenance Dose | 5mg to 10mg | 5mg to 10mg |
| Maximum Dose | 15mg | 15mg |
| Schedule | Inject once weekly at any time of day | Inject once weekly at any time of day |
| Titration | Start with 2.5mg for 4 weeks, then increase to 5mg. Can increase by 2.5mg every 4 weeks | Start with 2.5mg for 4 weeks, then increase to 5mg. Can increase by 2.5mg every 4 weeks |
Side Effects
Mounjaro
- •Nausea
- •Diarrhea
- •Decreased Appetite
- •Vomiting
- •Constipation
- •Indigestion
Zepbound
- •Nausea
- •Diarrhea
- •Decreased Appetite
- •Vomiting
- •Constipation
- •Indigestion
Practical Information
Mounjaro
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 21 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Growing coverage for diabetes, may require prior authorization
Clinical Results
- Weight Loss: 15-20%
- Study Duration: 72 weeks
- Study: SURMOUNT-1 trial
Zepbound
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 21 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-20%
- Study Duration: 72 weeks
- Study: SURMOUNT-1 trial
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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