Ozempic vs Byetta
Quick Facts
- Type: GLP-1
- FDA Approval: Ozempic (2017), Byetta (2005)
- Frequency: Once weekly
Weight Loss Data
- Ozempic: 12-14% in 68 weeks
- Byetta: 2-6% in 30 weeks
Primary Uses
- •Type 2 Diabetes
- •Weight Management
- •Cardiovascular Risk Reduction
Medication Overview
Ozempic
GLP-1Basic Information
- Generic Name: semaglutide
- Manufacturer: Novo Nordisk
- FDA Approval: 2017
Key Benefits
- ✓Significant A1C reduction
- ✓Weight loss support
- ✓Cardiovascular benefits
- ✓Once-weekly dosing
Byetta
GLP-1Basic Information
- Generic Name: exenatide
- Manufacturer: AstraZeneca
- FDA Approval: 2005
Key Benefits
- ✓Established safety profile
- ✓May reduce post-meal blood sugar spikes
- ✓Weight loss support
- ✓Long-term clinical experience
Dosing Information
| Dosing Details | Ozempic | Byetta |
|---|---|---|
| Starting Dose | 0.25mg | 5mcg |
| Maintenance Dose | 0.5mg to 1mg | 10mcg |
| Maximum Dose | 2mg | 10mcg |
| Schedule | Inject once weekly on the same day each week | Inject twice daily within 60 minutes before morning and evening meals |
| Titration | Start with 0.25mg for 4 weeks, then 0.5mg for at least 4 weeks before increasing if needed | Start with 5mcg twice daily for at least one month before increasing to 10mcg twice daily |
Side Effects
Ozempic
- •Nausea
- •Vomiting
- •Diarrhea
- •Abdominal Pain
- •Constipation
- •Decreased Appetite
Byetta
- •Nausea
- •Vomiting
- •Diarrhea
- •Feeling Jittery
- •Dizziness
- •Headache
Practical Information
Ozempic
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 56 days
- Needle Info: Comes with NovoFine® Plus needles
Insurance & Coverage
Widely covered for diabetes, may require prior authorization for weight management
Clinical Results
- Weight Loss: 12-14%
- Study Duration: 68 weeks
- Study: STEP 1 clinical trial
Byetta
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 30 days
- Needle Info: Requires separate pen needles
Insurance & Coverage
Generally covered for diabetes treatment
Clinical Results
- Weight Loss: 2-6%
- Study Duration: 30 weeks
- Study: Original clinical trials
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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