Saxenda vs Zepbound
Quick Facts
- Type: GLP-1 vs GLP-1/GIP
- FDA Approval: Saxenda (2014), Zepbound (2023)
- Frequency: Once daily
Weight Loss Data
- Saxenda: 5-10% in 56 weeks
- Zepbound: 15-20% in 72 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
Medication Overview
Saxenda
GLP-1Basic Information
- Generic Name: liraglutide
- Manufacturer: Novo Nordisk
- FDA Approval: 2014
Key Benefits
- ✓Established weight loss medication
- ✓Well-studied safety profile
- ✓May improve cardiovascular risk factors
- ✓Flexible dosing schedule
Zepbound
GLP-1/GIPBasic Information
- Generic Name: tirzepatide
- Manufacturer: Eli Lilly
- FDA Approval: 2023
Key Benefits
- ✓Significant weight loss potential
- ✓Dual-action mechanism
- ✓Once-weekly dosing
- ✓Improved metabolic health
Dosing Information
| Dosing Details | Saxenda | Zepbound |
|---|---|---|
| Starting Dose | 0.6mg | 2.5mg |
| Maintenance Dose | 3.0mg | 5mg to 10mg |
| Maximum Dose | 3.0mg | 15mg |
| Schedule | Inject once daily at any time of day | Inject once weekly at any time of day |
| Titration | Start with 0.6mg, increase by 0.6mg weekly until reaching 3.0mg | Start with 2.5mg for 4 weeks, then increase to 5mg. Can increase by 2.5mg every 4 weeks |
Side Effects
Saxenda
- •Nausea
- •Diarrhea
- •Constipation
- •Vomiting
- •Injection Site Reactions
- •Low Blood Sugar
Zepbound
- •Nausea
- •Diarrhea
- •Decreased Appetite
- •Vomiting
- •Constipation
- •Indigestion
Practical Information
Saxenda
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 30 days
- Needle Info: Comes with NovoFine® needles
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 5-10%
- Study Duration: 56 weeks
- Study: SCALE clinical trial program
Zepbound
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 21 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-20%
- Study Duration: 72 weeks
- Study: SURMOUNT-1 trial
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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