Trulicity vs Bydureon
Quick Facts
- Type: GLP-1
- FDA Approval: Trulicity (2014), Bydureon (2012)
- Frequency: Once weekly
Weight Loss Data
- Trulicity: 2-6% in 52 weeks
- Bydureon: 2-4% in 24 weeks
Primary Uses
- •Type 2 Diabetes
- •Cardiovascular Risk Reduction
Medication Overview
Trulicity
GLP-1Basic Information
- Generic Name: dulaglutide
- Manufacturer: Eli Lilly
- FDA Approval: 2014
Key Benefits
- ✓Once-weekly dosing
- ✓Ready-to-use pen
- ✓Cardiovascular benefits
- ✓No dose titration required for standard dose
Bydureon
GLP-1Basic Information
- Generic Name: exenatide extended-release
- Manufacturer: AstraZeneca
- FDA Approval: 2012
Key Benefits
- ✓Once-weekly dosing
- ✓No dose titration needed
- ✓Steady medication levels
- ✓Established safety profile
Dosing Information
| Dosing Details | Trulicity | Bydureon |
|---|---|---|
| Starting Dose | 0.75mg | 2mg |
| Maintenance Dose | 1.5mg | 2mg |
| Maximum Dose | 4.5mg | 2mg |
| Schedule | Inject once weekly at any time of day | Inject once weekly at any time of day |
| Titration | Start with 0.75mg, can increase to 1.5mg after 4 weeks if needed | No titration required, fixed 2mg dose |
Side Effects
Trulicity
- •Nausea
- •Diarrhea
- •Vomiting
- •Abdominal Pain
- •Decreased Appetite
- •Indigestion
Bydureon
- •Nausea
- •Diarrhea
- •Headache
- •Vomiting
- •Constipation
- •Injection Site Reactions
Practical Information
Trulicity
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 14 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Generally well-covered for diabetes treatment
Clinical Results
- Weight Loss: 2-6%
- Study Duration: 52 weeks
- Study: AWARD clinical trial program
Bydureon
Storage & Handling
- Storage: Refrigerate until use, do not freeze
- Needle Info: Comes with needles in kit
Insurance & Coverage
Generally covered for diabetes treatment
Clinical Results
- Weight Loss: 2-4%
- Study Duration: 24 weeks
- Study: DURATION clinical trials
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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