Trulicity vs Byetta
Quick Facts
- Type: GLP-1
- FDA Approval: Trulicity (2014), Byetta (2005)
- Frequency: Once weekly
Weight Loss Data
- Trulicity: 2-6% in 52 weeks
- Byetta: 2-6% in 30 weeks
Primary Uses
- •Type 2 Diabetes
- •Cardiovascular Risk Reduction
Medication Overview
Trulicity
GLP-1Basic Information
- Generic Name: dulaglutide
- Manufacturer: Eli Lilly
- FDA Approval: 2014
Key Benefits
- ✓Once-weekly dosing
- ✓Ready-to-use pen
- ✓Cardiovascular benefits
- ✓No dose titration required for standard dose
Byetta
GLP-1Basic Information
- Generic Name: exenatide
- Manufacturer: AstraZeneca
- FDA Approval: 2005
Key Benefits
- ✓Established safety profile
- ✓May reduce post-meal blood sugar spikes
- ✓Weight loss support
- ✓Long-term clinical experience
Dosing Information
| Dosing Details | Trulicity | Byetta |
|---|---|---|
| Starting Dose | 0.75mg | 5mcg |
| Maintenance Dose | 1.5mg | 10mcg |
| Maximum Dose | 4.5mg | 10mcg |
| Schedule | Inject once weekly at any time of day | Inject twice daily within 60 minutes before morning and evening meals |
| Titration | Start with 0.75mg, can increase to 1.5mg after 4 weeks if needed | Start with 5mcg twice daily for at least one month before increasing to 10mcg twice daily |
Side Effects
Trulicity
- •Nausea
- •Diarrhea
- •Vomiting
- •Abdominal Pain
- •Decreased Appetite
- •Indigestion
Byetta
- •Nausea
- •Vomiting
- •Diarrhea
- •Feeling Jittery
- •Dizziness
- •Headache
Practical Information
Trulicity
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 14 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Generally well-covered for diabetes treatment
Clinical Results
- Weight Loss: 2-6%
- Study Duration: 52 weeks
- Study: AWARD clinical trial program
Byetta
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 30 days
- Needle Info: Requires separate pen needles
Insurance & Coverage
Generally covered for diabetes treatment
Clinical Results
- Weight Loss: 2-6%
- Study Duration: 30 weeks
- Study: Original clinical trials
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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