Wegovy vs Bydureon
Quick Facts
- Type: GLP-1
- FDA Approval: Wegovy (2021), Bydureon (2012)
- Frequency: Once weekly
Weight Loss Data
- Wegovy: 15-17% in 68 weeks
- Bydureon: 2-4% in 24 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
- •Type 2 Diabetes
Medication Overview
Wegovy
GLP-1Basic Information
- Generic Name: semaglutide
- Manufacturer: Novo Nordisk
- FDA Approval: 2021
Key Benefits
- ✓Significant weight loss potential
- ✓Once-weekly dosing
- ✓Improved cardiovascular markers
- ✓Established safety profile
Bydureon
GLP-1Basic Information
- Generic Name: exenatide extended-release
- Manufacturer: AstraZeneca
- FDA Approval: 2012
Key Benefits
- ✓Once-weekly dosing
- ✓No dose titration needed
- ✓Steady medication levels
- ✓Established safety profile
Dosing Information
| Dosing Details | Wegovy | Bydureon |
|---|---|---|
| Starting Dose | 0.25mg | 2mg |
| Maintenance Dose | 1mg to 1.7mg | 2mg |
| Maximum Dose | 2.4mg | 2mg |
| Schedule | Inject once weekly on the same day each week | Inject once weekly at any time of day |
| Titration | Start with 0.25mg, increase every 4 weeks through 0.5mg, 1mg, 1.7mg to reach 2.4mg | No titration required, fixed 2mg dose |
Side Effects
Wegovy
- •Nausea
- •Diarrhea
- •Vomiting
- •Constipation
- •Abdominal Pain
- •Headache
Bydureon
- •Nausea
- •Diarrhea
- •Headache
- •Vomiting
- •Constipation
- •Injection Site Reactions
Practical Information
Wegovy
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 56 days
- Needle Info: Comes with NovoFine® Plus needles
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-17%
- Study Duration: 68 weeks
- Study: STEP clinical trial program
Bydureon
Storage & Handling
- Storage: Refrigerate until use, do not freeze
- Needle Info: Comes with needles in kit
Insurance & Coverage
Generally covered for diabetes treatment
Clinical Results
- Weight Loss: 2-4%
- Study Duration: 24 weeks
- Study: DURATION clinical trials
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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