Wegovy vs Byetta
Quick Facts
- Type: GLP-1
- FDA Approval: Wegovy (2021), Byetta (2005)
- Frequency: Once weekly
Weight Loss Data
- Wegovy: 15-17% in 68 weeks
- Byetta: 2-6% in 30 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
- •Type 2 Diabetes
Medication Overview
Wegovy
GLP-1Basic Information
- Generic Name: semaglutide
- Manufacturer: Novo Nordisk
- FDA Approval: 2021
Key Benefits
- ✓Significant weight loss potential
- ✓Once-weekly dosing
- ✓Improved cardiovascular markers
- ✓Established safety profile
Byetta
GLP-1Basic Information
- Generic Name: exenatide
- Manufacturer: AstraZeneca
- FDA Approval: 2005
Key Benefits
- ✓Established safety profile
- ✓May reduce post-meal blood sugar spikes
- ✓Weight loss support
- ✓Long-term clinical experience
Dosing Information
| Dosing Details | Wegovy | Byetta |
|---|---|---|
| Starting Dose | 0.25mg | 5mcg |
| Maintenance Dose | 1mg to 1.7mg | 10mcg |
| Maximum Dose | 2.4mg | 10mcg |
| Schedule | Inject once weekly on the same day each week | Inject twice daily within 60 minutes before morning and evening meals |
| Titration | Start with 0.25mg, increase every 4 weeks through 0.5mg, 1mg, 1.7mg to reach 2.4mg | Start with 5mcg twice daily for at least one month before increasing to 10mcg twice daily |
Side Effects
Wegovy
- •Nausea
- •Diarrhea
- •Vomiting
- •Constipation
- •Abdominal Pain
- •Headache
Byetta
- •Nausea
- •Vomiting
- •Diarrhea
- •Feeling Jittery
- •Dizziness
- •Headache
Practical Information
Wegovy
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 56 days
- Needle Info: Comes with NovoFine® Plus needles
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-17%
- Study Duration: 68 weeks
- Study: STEP clinical trial program
Byetta
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 30 days
- Needle Info: Requires separate pen needles
Insurance & Coverage
Generally covered for diabetes treatment
Clinical Results
- Weight Loss: 2-6%
- Study Duration: 30 weeks
- Study: Original clinical trials
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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