Wegovy vs Lyxumia
Quick Facts
- Type: GLP-1
- FDA Approval: Wegovy (2021), Lyxumia (2016)
- Frequency: Once weekly
Weight Loss Data
- Wegovy: 15-17% in 68 weeks
- Lyxumia: 2-4% in 24 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
- •Type 2 Diabetes
Medication Overview
Wegovy
GLP-1Basic Information
- Generic Name: semaglutide
- Manufacturer: Novo Nordisk
- FDA Approval: 2021
Key Benefits
- ✓Significant weight loss potential
- ✓Once-weekly dosing
- ✓Improved cardiovascular markers
- ✓Established safety profile
Lyxumia
GLP-1Basic Information
- Generic Name: lixisenatide
- Manufacturer: Sanofi
- FDA Approval: 2016
Key Benefits
- ✓Once-daily dosing
- ✓Reduces post-meal glucose levels
- ✓Simple titration schedule
- ✓Can be used with basal insulin
Dosing Information
| Dosing Details | Wegovy | Lyxumia |
|---|---|---|
| Starting Dose | 0.25mg | 10mcg |
| Maintenance Dose | 1mg to 1.7mg | 20mcg |
| Maximum Dose | 2.4mg | 20mcg |
| Schedule | Inject once weekly on the same day each week | Inject once daily within one hour before the first meal of the day |
| Titration | Start with 0.25mg, increase every 4 weeks through 0.5mg, 1mg, 1.7mg to reach 2.4mg | Start with 10mcg daily for 14 days, then increase to 20mcg daily |
Side Effects
Wegovy
- •Nausea
- •Diarrhea
- •Vomiting
- •Constipation
- •Abdominal Pain
- •Headache
Lyxumia
- •Nausea
- •Vomiting
- •Diarrhea
- •Headache
- •Dizziness
- •Injection Site Reactions
Practical Information
Wegovy
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 56 days
- Needle Info: Comes with NovoFine® Plus needles
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-17%
- Study Duration: 68 weeks
- Study: STEP clinical trial program
Lyxumia
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 14 days
- Needle Info: Requires separate pen needles
Insurance & Coverage
Coverage varies by region and insurance plan
Clinical Results
- Weight Loss: 2-4%
- Study Duration: 24 weeks
- Study: GetGoal clinical trial program
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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