Wegovy vs Zepbound
Quick Facts
- Type: GLP-1 vs GLP-1/GIP
- FDA Approval: Wegovy (2021), Zepbound (2023)
- Frequency: Once weekly
Weight Loss Data
- Wegovy: 15-17% in 68 weeks
- Zepbound: 15-20% in 72 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
Medication Overview
Wegovy
GLP-1Basic Information
- Generic Name: semaglutide
- Manufacturer: Novo Nordisk
- FDA Approval: 2021
Key Benefits
- ✓Significant weight loss potential
- ✓Once-weekly dosing
- ✓Improved cardiovascular markers
- ✓Established safety profile
Zepbound
GLP-1/GIPBasic Information
- Generic Name: tirzepatide
- Manufacturer: Eli Lilly
- FDA Approval: 2023
Key Benefits
- ✓Significant weight loss potential
- ✓Dual-action mechanism
- ✓Once-weekly dosing
- ✓Improved metabolic health
Dosing Information
| Dosing Details | Wegovy | Zepbound |
|---|---|---|
| Starting Dose | 0.25mg | 2.5mg |
| Maintenance Dose | 1mg to 1.7mg | 5mg to 10mg |
| Maximum Dose | 2.4mg | 15mg |
| Schedule | Inject once weekly on the same day each week | Inject once weekly at any time of day |
| Titration | Start with 0.25mg, increase every 4 weeks through 0.5mg, 1mg, 1.7mg to reach 2.4mg | Start with 2.5mg for 4 weeks, then increase to 5mg. Can increase by 2.5mg every 4 weeks |
Side Effects
Wegovy
- •Nausea
- •Diarrhea
- •Vomiting
- •Constipation
- •Abdominal Pain
- •Headache
Zepbound
- •Nausea
- •Diarrhea
- •Decreased Appetite
- •Vomiting
- •Constipation
- •Indigestion
Practical Information
Wegovy
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 56 days
- Needle Info: Comes with NovoFine® Plus needles
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-17%
- Study Duration: 68 weeks
- Study: STEP clinical trial program
Zepbound
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 21 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-20%
- Study Duration: 72 weeks
- Study: SURMOUNT-1 trial
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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