Zepbound vs Bydureon
Quick Facts
- Type: GLP-1/GIP vs GLP-1
- FDA Approval: Zepbound (2023), Bydureon (2012)
- Frequency: Once weekly
Weight Loss Data
- Zepbound: 15-20% in 72 weeks
- Bydureon: 2-4% in 24 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
- •Type 2 Diabetes
Medication Overview
Zepbound
GLP-1/GIPBasic Information
- Generic Name: tirzepatide
- Manufacturer: Eli Lilly
- FDA Approval: 2023
Key Benefits
- ✓Significant weight loss potential
- ✓Dual-action mechanism
- ✓Once-weekly dosing
- ✓Improved metabolic health
Bydureon
GLP-1Basic Information
- Generic Name: exenatide extended-release
- Manufacturer: AstraZeneca
- FDA Approval: 2012
Key Benefits
- ✓Once-weekly dosing
- ✓No dose titration needed
- ✓Steady medication levels
- ✓Established safety profile
Dosing Information
| Dosing Details | Zepbound | Bydureon |
|---|---|---|
| Starting Dose | 2.5mg | 2mg |
| Maintenance Dose | 5mg to 10mg | 2mg |
| Maximum Dose | 15mg | 2mg |
| Schedule | Inject once weekly at any time of day | Inject once weekly at any time of day |
| Titration | Start with 2.5mg for 4 weeks, then increase to 5mg. Can increase by 2.5mg every 4 weeks | No titration required, fixed 2mg dose |
Side Effects
Zepbound
- •Nausea
- •Diarrhea
- •Decreased Appetite
- •Vomiting
- •Constipation
- •Indigestion
Bydureon
- •Nausea
- •Diarrhea
- •Headache
- •Vomiting
- •Constipation
- •Injection Site Reactions
Practical Information
Zepbound
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 21 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-20%
- Study Duration: 72 weeks
- Study: SURMOUNT-1 trial
Bydureon
Storage & Handling
- Storage: Refrigerate until use, do not freeze
- Needle Info: Comes with needles in kit
Insurance & Coverage
Generally covered for diabetes treatment
Clinical Results
- Weight Loss: 2-4%
- Study Duration: 24 weeks
- Study: DURATION clinical trials
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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