Zepbound vs Byetta
Quick Facts
- Type: GLP-1/GIP vs GLP-1
- FDA Approval: Zepbound (2023), Byetta (2005)
- Frequency: Once weekly
Weight Loss Data
- Zepbound: 15-20% in 72 weeks
- Byetta: 2-6% in 30 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
- •Type 2 Diabetes
Medication Overview
Zepbound
GLP-1/GIPBasic Information
- Generic Name: tirzepatide
- Manufacturer: Eli Lilly
- FDA Approval: 2023
Key Benefits
- ✓Significant weight loss potential
- ✓Dual-action mechanism
- ✓Once-weekly dosing
- ✓Improved metabolic health
Byetta
GLP-1Basic Information
- Generic Name: exenatide
- Manufacturer: AstraZeneca
- FDA Approval: 2005
Key Benefits
- ✓Established safety profile
- ✓May reduce post-meal blood sugar spikes
- ✓Weight loss support
- ✓Long-term clinical experience
Dosing Information
| Dosing Details | Zepbound | Byetta |
|---|---|---|
| Starting Dose | 2.5mg | 5mcg |
| Maintenance Dose | 5mg to 10mg | 10mcg |
| Maximum Dose | 15mg | 10mcg |
| Schedule | Inject once weekly at any time of day | Inject twice daily within 60 minutes before morning and evening meals |
| Titration | Start with 2.5mg for 4 weeks, then increase to 5mg. Can increase by 2.5mg every 4 weeks | Start with 5mcg twice daily for at least one month before increasing to 10mcg twice daily |
Side Effects
Zepbound
- •Nausea
- •Diarrhea
- •Decreased Appetite
- •Vomiting
- •Constipation
- •Indigestion
Byetta
- •Nausea
- •Vomiting
- •Diarrhea
- •Feeling Jittery
- •Dizziness
- •Headache
Practical Information
Zepbound
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 21 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-20%
- Study Duration: 72 weeks
- Study: SURMOUNT-1 trial
Byetta
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 30 days
- Needle Info: Requires separate pen needles
Insurance & Coverage
Generally covered for diabetes treatment
Clinical Results
- Weight Loss: 2-6%
- Study Duration: 30 weeks
- Study: Original clinical trials
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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