Zepbound vs Trulicity
Quick Facts
- Type: GLP-1/GIP vs GLP-1
- FDA Approval: Zepbound (2023), Trulicity (2014)
- Frequency: Once weekly
Weight Loss Data
- Zepbound: 15-20% in 72 weeks
- Trulicity: 2-6% in 52 weeks
Primary Uses
- •Weight Management
- •Obesity Treatment
- •Type 2 Diabetes
- •Cardiovascular Risk Reduction
Medication Overview
Zepbound
GLP-1/GIPBasic Information
- Generic Name: tirzepatide
- Manufacturer: Eli Lilly
- FDA Approval: 2023
Key Benefits
- ✓Significant weight loss potential
- ✓Dual-action mechanism
- ✓Once-weekly dosing
- ✓Improved metabolic health
Trulicity
GLP-1Basic Information
- Generic Name: dulaglutide
- Manufacturer: Eli Lilly
- FDA Approval: 2014
Key Benefits
- ✓Once-weekly dosing
- ✓Ready-to-use pen
- ✓Cardiovascular benefits
- ✓No dose titration required for standard dose
Dosing Information
| Dosing Details | Zepbound | Trulicity |
|---|---|---|
| Starting Dose | 2.5mg | 0.75mg |
| Maintenance Dose | 5mg to 10mg | 1.5mg |
| Maximum Dose | 15mg | 4.5mg |
| Schedule | Inject once weekly at any time of day | Inject once weekly at any time of day |
| Titration | Start with 2.5mg for 4 weeks, then increase to 5mg. Can increase by 2.5mg every 4 weeks | Start with 0.75mg, can increase to 1.5mg after 4 weeks if needed |
Side Effects
Zepbound
- •Nausea
- •Diarrhea
- •Decreased Appetite
- •Vomiting
- •Constipation
- •Indigestion
Trulicity
- •Nausea
- •Diarrhea
- •Vomiting
- •Abdominal Pain
- •Decreased Appetite
- •Indigestion
Practical Information
Zepbound
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 21 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Variable coverage for weight management, often requires prior authorization
Clinical Results
- Weight Loss: 15-20%
- Study Duration: 72 weeks
- Study: SURMOUNT-1 trial
Trulicity
Storage & Handling
- Storage: Refrigerate until first use, then can be stored at room temperature for up to 14 days
- Needle Info: Comes with attached hidden needle
Insurance & Coverage
Generally well-covered for diabetes treatment
Clinical Results
- Weight Loss: 2-6%
- Study Duration: 52 weeks
- Study: AWARD clinical trial program
Medical Disclaimer: This comparison is for informational purposes only and should not replace professional medical advice. Always consult with your healthcare provider about which medication is right for you. Treatment decisions should be based on your individual medical needs and circumstances.
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